Diffuse malignant pleural mesothelioma pathological changes

Diffuse malignant pleural mesothelioma along the pleural surface growth, can occur in the layer, visceral and mediastinal pleura. Difficult to distinguish between lesion site of origin. Cancer and lung often directly stromal invasion, a nodular mass. Tumor Duocheng off-white, some due to partial necrosis and yellow, hard texture. And often transferred to the hilar lymph node, or through the blood transfer to the lung, liver, brain and adrenal gland. Because of the diversity of skin organization, thus its characteristics and classification than the complex. Normally be divided into E-, sarcomatoid type (fiber) and mixed three types, more than skin-多见. Single-use optical microscopy often difficult to E-malignant pleural mesothelioma and lung cancer, such as the transfer of distinction. Using immunohistochemistry and electron microscopy to identify. Malignant pleural mesothelioma low-molecular-weight keratin were positive, with sarcoma can be separated malignant pleural mesothelioma can not be CEA (carcinoembryonic antigen) stain, which can be differentiated adenocarcinoma. If the immune group of the same results with other tumors, electron microscopy can generally be confirmed. Malignant pleural mesothelioma the most notable feature is that many of bending the microvilli, and adenocarcinoma microvilli short and straight, and a layer of coverage above polysaccharide protein complex.