Peritoneal mesothelioma clinical stage

Peritoneal mesothelioma (peritoneal mesothelioma) in the primary peritoneal mesothelial organizations and epithelial tumors, clinical rarely see. Pathology, may be divided into adenomatous mesothelioma (adenomatoid mesothelioma), cystic mesothelioma (cystic mesothelioma) and malignant mesothelioma (peritoneal malignant mesothelioma, PMM).

Peritoneal mesothelioma (peritoneal mesothelioma) in the primary peritoneal mesothelial organizations and epithelial tumors, clinical rarely see. Pathology, may be divided into adenomatous mesothelioma (adenomatoid mesothelioma), cystic mesothelioma (cystic mesothelioma) and malignant mesothelioma (peritoneal malignant mesothelioma, PMM). The first two are benign. Cystic mesothelioma more common in women, cause unknown, occurred in the surrounding pelvic or annex, a single or multiple cystic mass; patients often palpable abdominal mass and treatment. Malignant peritoneal mesothelioma (PMM) malignant mesothelioma about 30 percent of its occurrence and also closely related to exposure to asbestos, about 5 percent of patients have a history of exposure; asbestos fiber intake by mouth, through the intestinal wall to the translocation Peritoneal and pleural disease or from the transfer from. From exposure to asbestos-diagnosed, the disease incubation period of up to 25 to 40 years. However, domestic 1951 to 1993 20 PMM literature reports 161 cases, only one case of a history of exposure to asbestos. Zhou Ya Kang, and other reports of 47 cases of mesothelioma in eight cases of malignant peritoneal mesothelioma, and I gather the two cases have a history of exposure to asbestos. No history of exposure to asbestos in the crowd, the incidence rate of about 1 / 1 million years, and some may be infected with the virus and genetic factors. Foreign PMM reported one case of patients over 40 years ago, glial contact with thorium dioxide (Thorotrast). PMM often occurred in more than 40-year-old male. Dirty floor or layer can Li and peritoneal tumor can be a direct violation of abdominal, pelvic organ; 50 percent to 70 percent of patients with lymph node and / or blood transfer of liver, kidney and adrenal gland, lung, bone, and so on.

PMM clinical performance of the lack of specificity, may have abdominal pain, constipation, abdominal distension, weight loss and other obstruction performance. Physical examination can be found ascites or peritoneal mass, and so on. Ascites for effusion, some bloody. The disease often misdiagnosed as tuberculosis peritonitis, recurrent spontaneous peritonitis, inflammation or mesenteric peritoneal metastasis, and so on. Ascites hyaluronic acid increased significantly greater than 0.8 g / L were found only in PMM. Ascites exfoliated cells also check some value, but often difficult to judge. Serum carbohydrate antigen -125 (CA125) increased to help diagnosis of the disease.

Clinical stages: Butchart and other PMM will be divided into four: I tumors confined to the peritoneum; Ⅱ period of intra-abdominal lymph node cancer; Ⅲ period to the abdominal tumor metastasis outside; Ⅳ blood of distant metastasis. Categories will help choose the treatment. PMM so far no effective standardized treatment. Poor prognosis, diagnosis after the median survival period for one year, survived more than two years to less than 20%. Mainly from the evil of quality or obstruction, and rarely cause of death related to cancer metastasis.