Progesterone may rule of endometrial cancer

Although endometrial cancer surgery is the most important means of treatment, but because progesterone can direct role in the tumor cells and inhibit endometrial hyperplasia, to promote normal cells into cancer cells, it can to a certain extent, improve the patient's symptoms and prolong Patients with no progress survival.
Progesterone may rule of endometrial cancer


Normal women's menstruation, fertility and good health on a variety of endocrine hormones to maintain. Various hormone mutual constraints in order to maintain the body's balance, once that balance was destroyed, the body's many functions will be affected, and even caused many troubles of the disease.

For example, progesterone is female puberty, ovarian produce a hormone essential for it to dominate the women's normal menstrual cycle, can promote the development of women Second Sex levy, maintaining the embryo in the womb of healthy growth. If the body does not secretion of progesterone or inadequate, not only will lead to menstrual disorders, menopause, pregnancy after the abortion, and women in many important physiological functions are not functioning properly. In addition, many people may not know that the progesterone in endometrial cancer patients in the treatment, but also serve as a very important role.

Although endometrial cancer surgery is the most important means of treatment, but because progesterone can direct role in the tumor cells and inhibit endometrial hyperplasia, to promote normal cells into cancer cells, can to some extent improved the patient's symptoms and prolong Patients with no progress survival. Apply mainly to those progesterone receptor-positive, can not be advanced surgical resection, the recurrence of endometrial cancer patients.

Now, the general clinical use of long-term progesterone treatment of endometrial cancer, including commonly used a progesterone acetate, acetic acid, such as megestrol acetate. Principle is to use large doses, long time. It is worth noting that the use of high-dose progesterone, first, should be used in postoperative patients with endometrial samples of estrogen and progesterone receptor inspection to determine the effectiveness of progesterone hormone therapy, estrogen receptor and progesterone Hormone receptor-positive patients with good effect, the total efficiency to achieve 20 percent to 30 percent. Second, the tumor cells to check the degree of differentiation, and differentiation good effect better differentiation of poor efficiency is only 9%.

However, at home and abroad in recent years, a lot of evidence-based medicine study found that the use of progesterone to raise certain types of endometrial cancer patients overall survival not very meaningful. This may be treated with progesterone on the side-effects, progesterone Although no general chemotherapy drugs inhibit bone marrow, and other serious adverse reactions, but often will cause the patient Shuinazhuliu, weight gain, with thromboembolic disease, such as increasing the risk. Therefore, patients must be under the guidance of doctors in the treatment, when used with a lot more, but not for the random.