Jul 23, 2008

Endometrial cancer treatment Daquan

The request to retain the age of fertility patients, in recent years has proved that through the resumption of ovulation, so that reversal for the secretion of endometrial lesions period will disappear. However, due to risk factors may still exist, so these women should conduct regular follow-up. For beyond childbearing age to the adenomatous hyperplasia, hysterectomy is the preferred therapy.

Palace of cancer treatment to surgery, radiotherapy and chemotherapy. Operation scope and radiotherapy, chemotherapy for a reasonable choice, the prognosis depends directly on the impact of various factors.

The adenomatous hyperplasia, or 0 in the treatment of patients depend on the age and fertility requirements. The request to retain the age of fertility patients, in recent years has proved that through the resumption of ovulation, so that reversal for the secretion of endometrial lesions period will disappear. However, due to risk factors may still exist, so these women should conduct regular follow-up. For beyond childbearing age to the adenomatous hyperplasia, hysterectomy is the preferred therapy.

(1) treatment

Has a relatively consistent view that the majority of Ⅰ and Ⅱ stage endometrial cancer cured through surgery. For G1 Ⅰ a period of uterine cancer through the entire two-plus annex with cured.

Ⅰ period poorly differentiated cancer (G2 and G3) to increase bilateral hysterectomy and removal of the annex to the effect of radiotherapy is better than surgery alone. When the uterine cavity diameter> 10 cm, this combination therapy also suitable.

Ⅱ stage endometrial cancer and cervical cancer treatment for that trip extensive hysterectomy and pelvic lymph node dissection. However, today reported the best results is through in vitro and brachytherapy hysterectomy later, the comprehensive treatment. This may be due to Palace of cancer than the general development of the slow, the majority of lesions confined to the uterus, even if Gongpang and may be transferred to the pelvic lymph nodes, radiation therapy before operation is expected to kill cancer and to reduce the Palace of the Ministry of cancer, Even then extensive surgery can not cure; the other hand, the Palace of the majority of cancer patients have Nianguobanbai, many are obese, and have important medical complications such as diabetes, hypertension and other inappropriate to hysterectomy and the wider region Resection of lymph nodes, the preoperative radiotherapy combined with its support effectiveness.

(2) radiation therapy

For the effect of radiation and application methods remain controversial. But the general view that the stage Ⅰ Ⅰ-class, non-muscular violations, simple operation can be. The stage Ⅰ poorly differentiated cancer (Ⅱ, Ⅲ level), muscular violations of> 1 / 2, metastasis, as well as the stage Ⅱ endometrial cancer, the use of endovascular laser treatment of pre-trip after hysterectomy and bilateral Annex Resection and postoperative radiation in vitro.

Ⅰ treatment of endometrial cancer also based on pathology division, tumor-infiltrating muscle depth, and abdominal lymph node metastasis exfoliated cells is positive, comprehensive radiation therapy to consider suitable to enhance the cure rate.

In addition, the combination of chemotherapy or radiotherapy alone for many elderly patients, surgery contraindications, as well as a small number of advanced disease with multiple organ involvement or removal of the tumor can not be caused by bleeding palliative care.

Late recurrence of cancer and cancer treatment: Ⅲ, Ⅳ of cancer do not completely removed by surgery, radiation therapy in general use (endovascular laser treatment and in vitro exposure) and chemotherapy. Endometrial cancer the most common site is the recurrence of pelvic and vaginal Qionglong Bu and separated. If the pelvic recurrence, hysterectomy is not to the radiation patients, at this time should first radiotherapy, which includes all pelvic and vaginal built-in vitro exposure cesium or radium treatment.

(3) hormones and chemical treatment

As mentioned earlier, progesterone can dysplasia of endometrial changes for the production period or atrophic endometrium, which can lead to endometrial hyperplasia, or adenomas adenoma shrinking, reversed. About 1 / 3 of advanced or recurrent endometrial cancer patients on the effective progesterone preparations, especially for lung metastasis best effect, about 35% of patients with a significant response. But within the pelvic recurrence or continuation of the lesion to perform well.

Progesterone treatment of the biggest advantages of adverse reactions is small, especially with general chemotherapy drugs inhibit bone marrow of serious adverse reactions, and the application of convenience, not hospitalized, but occasionally the injection site pain, redness, swelling a small number of patients with mild , High blood pressure, acne and boils swollen glands, such as pregnancy, but can be tolerated, the patients willing to accept. Jiyong patients with liver dysfunction.

Progesterone treatment and other cytotoxic anti-cancer drugs like chemotherapy as palliative rather than a radical. At present the most commonly used progesterone preparations are 17 - hydroxy acid or progesterone and progesterone acetate megestrol acetate. Recently reported that estrogen antagonist on the primary tumor is estrogen receptor-positive disease recurrence effective, or when progesterone treatment failure, the effective application of the drug.

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